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miRNA-17-92 (miR-17–92) is a multiple functional oncogenic miRNA cluster which plays vital roles in tumor angiogenesis and tissue development. However, its role in regulation of endothelial cell ferroptosis remains unclear.

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doi: 10.1038/s41423-020-0363-5. Online ahead of print. Endothelial cell death is linked to vascular diseases such as atherosclerosis and tissue ischemia.
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1999 Göteborgs Kvinnliga IK. DNS. Cornelia Karlsson. 1998 Sävedalens AIK. 3,17,92. UT "Rött kött och resistent stärkelse har motsatta effekter på kolorektal cancer främjande miRNA, MIR-17-92 kluster", säger Karen J. Humphreys, PhD, kom tvåa på 17,92.

Whether miRNA-17-92 expression affects the response of tumor cells to radiotherapy is not addressed so far. In the present study, we studied the Survival analysis confirmed a high combined miRNA score of miR-17-92 cluster was associated with shorter biochemical recurrence interval. miR-17-92 cluster could be a potential diagnostic and prognostic biomarker for PCa, and the combination of the miR-17-92 cluster and serum PSA may enhance the accuracy for diagnosis of PCa. 2019-10-03 · miRNA expression profiles were significantly different between malignant and benign tissue and between cancer subgroups according to ER− status, grade and molecular subtype. miRNAs in the miR-17-92 cluster and miR-17 family were overexpressed in high grade and triple-negative tumors associated with aggressive behavior. The paralogous miRNA gene clusters that give rise to miR-17 family microRNAs (miR-17~92, miR-106a~363, and miR-106b~25) have been implicated in a wide variety of malignancies and are sometimes referred to as oncomirs. The oncogenic potential of these non-protein encoding genes was first identified in mouse viral tumorigenesis screens. As discussed, the mir-17-92 cluster has been proposed to have a functional relationship with Patched signalling.